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StemEnhance
StemEnhance™,
a concentrated natural formula that increases the number
of circulating stem cells in your body by up to 30%
-- in a single dose!

Quick Facts on the new StemEnhance™ by Stem Tech:

Order StemEnhance now
•        Supports the natural & safe release of adult stem cells from the bone marrow
•        Supports the migration of stem cells to tissue in your body needing repair
•        Proven to increase the number of circulating stem cells by up to 30% (about 3 to 4 million stem
cells),
•        No ethical controversy; safe to use
•        Additional benefits include anti-inflammatory and immune system support, mental clarity and
mood elevation
•        Patented natural aquabotanical extract (Patent#: 6,814,961 B1)

Frequently Asked Questions

What is StemEnhance™?
StemEnhance™ is a breakthrough, natural botanical extract that supports wellness by helping your
body maintain healthy stem cell physiology. It is the very first product on the market from the latest
phytoceutical product category called “stem cell enhancers”.

What are stem cell enhancers?
Recent scientific developments have revealed that stem cells derived from the bone marrow, travel
throughout the body, and act to support optimal organ and tissue function. Stem cell enhancers are
products that support the natural role of adult stem cells.

Why do I need this product?
As you age, the number and quality of stem cells that circulate in your body gradually decrease,
leaving your body more susceptible to injury and other age-related health challenges.
Just as antioxidants are important to protect your cells from “free radical” damage, stem cell
enhancers are equally important to support your stem cells in maintaining proper organ and tissue
functioning in your body.

How does it work?
When you take two capsules, the ingredients help to support the release of stem cells from the bone
marrow into the bloodstream. Through a natural process, those stem cells then travel to areas of the
body where they are most needed. StemEnhance™ is a blend of two compounds extracted from the
aquatic botanical Aphanizomenon flos-aquae (AFA). One extract, which contains an L-selectin ligand,
supports the release of stem cells (CD34+ cells) from the bone marrow. The other extract, a
polysaccharide-rich fraction named Migratose™, may support the migration of stem cells out of the
blood into tissues.

What are stem cells?
Stem cells can be thought of as “master” cells. You’ve probably heard about the controversy of
embryonic stem cells in the news. Stem cells are found in human embryos, but are also found in adult
tissue.
Adult stem cells are most abundantly found in bone marrow. Stem cells circulate and function to
replace dysfunctional cells, thus fulfilling the natural process of maintaining optimal health.
StemEnhance™ supports the release of adult stem cells from bone marrow into circulation.
The recent advances in stem cell research were listed as one of the most significant health-related
stories in the past 25 years by CNN, second only to the complete mapping of the human genome.

What is the Stem Cell Theory of Renewal?
The Stem Cell Theory of Renewal proposes that stem cells are naturally released by the bone marrow
and travel via the bloodstream toward cells in need. When an organ is subjected to a challenge, this
organ releases compounds that trigger the release of stem cells from the bone marrow. The organ
also releases compound that attracts stem cells to this organ. The released stem cells then follow the
concentration gradient of these compounds and leave to blood circulation to migrate in the organ
where they proliferate and differentiate into cells of this organ.

Why do we hear much in the news about embryonic stem cells and very little about adult stem cells?
The first human embryonic stem cells were grown in vitro, in a petri dish, in the mid 1990s. Rapidly,
scientists were successful at growing them for many generations and to trigger their differentiation
into virtually any kind of cells, i.e. brain cells, heart cells, liver cells, bone cells, pancreatic cells, etc.
When scientists tried growing adult stem cells, the endeavor was met with less success, as adult
stem cells were difficult to grow in vitro for more than a few generations. This led to the idea that
embryonic stem cells have more potential than adult stem cells. In addition, the ethical concerns
linked to the use of embryonic stem cells has led to a disproportion representation of embryonic
stem cells in the media. But recent developments over the past 2-3 years have established that adult
stem cells have capabilities comparable to embryonic stem cells in the human body, not in the test
tube. Many studies have shown that simply releasing stem cell from the bone marrow can lead to
optimal health

What is the science behind StemEnhance?
The effect of StemEnhance™ on stem cells was tested in a triple-blind study. In brief, volunteers
rested for one hour before the first blood sample, which established the baseline level in the number
of circulating stem cells. After the first blood samples, volunteers were given StemEnhance™ or
placebo. Thereafter, blood samples were taken at 30, 60 and 120 minutes after taking the
consumables. The number of circulating stem cells was quantified by analyzing the blood samples
using Fluorescence-Activated Cell Sorting (FACS). Consumption of StemEnhance™ triggered a
significant 25% increase in the number of circulating stem cells.

How does an increase in the number of circulating stem cells lead to optimal health?
Circulating stem cells can reach various organs and become cells of that organ, helping such organ
regain and maintain optimal health. Recent studies have suggested that the number of circulating
stem cells is a key factor; the higher the number of circulating stem cells the greater is the ability of
the body at healing itself.

What is the recommended dose?
One gram of StemEnhance™ triggers a significant 25-35% increase in the number of circulating stem
cells. The effect lasts for a few hours. The recommended dosage is therefore 2 capsules once or
twice day, at least 6 hours apart.

What is the optimum way of taking StemEnhance capsules?
StemEnhance can be taken with or without food, though some people at times experience some
heaviness when taken on an empty stomach. The same experience has been reported when taken
with an acidic juice like orange juice. Otherwise, StemEnhance can be taken with any fruit or
vegetable juice, or with water. In our studies, StemEnhance was always taken in the morning.
However, it is quite possible that StemEnhance might bring greater benefits when taken before
sleep, as the body tends to regenerate better during sleep. This being said, this remains to be
studied. At this point, with the data available, the best way to take StemEnhance is to take 2 capsules
once or twice a day, in the morning, or morning and evening.

Can StemEnhance™ deplete the bone marrow? Do we have a finite number of stem cells?
No, StemEnhance™ will not deplete the bone marrow. The bone marrow constantly produces stem
cells for the entire life of an individual. Stem cells released by the bone marrow are responsible for
the constant renewal of red blood cells and lymphocytes (immune cells). A 25-30% increase in the
number of circulating stem cells is well within physiological range and does not constitute stress on
the bona marrow environment. The amount of active bone marrow amounts to about 2,600 g (5.7 lbs),
with about 1.3 trillion marrow cells. A 25-30% increase in the number of circulating stem cells
triggered by the consumption of 1 gram of StemEnhance™ corresponds to approximately 3 million
cells, which is 0.0003% of the stem cells present in the bone marrow

What happens to stem cells if they do not reach a tissue?
Stem cells released from the bone marrow that do not reach a tissue simply return to the bone
marrow after some time

Why may StemEnhance™ be contraindicated for people on anticoagulant therapy?
One gram of StemEnhance contains roughly half of the recommended daily allowance in vitamin K.
Vitamin K is an essential nutrient playing an important role in the process of blood coagulation.
However, when one experiences cardiovascular problems, oftentimes doctors will elect to put a one
of anticoagulant therapy in order to prevent blood clot and make it easier for the heart to pump blood
through the body. Since vitamin K promotes blood coagulation, it is customary to tell people to avoid
vitamin K while being on anticoagulant therapy. This being said, it is not so much the presence of
vitamin K in the diet as much as the consistency in the daily intake. Therefore, the best approach is to
discuss with your doctor about your desire to take StemEnhance, that it contains vitamin K, and the
anticoagulant prescription can be adjusted through careful monitoring of your condition by your
doctor.

Can StemEnhance be taken with other drugs?
As far as we have studied and researched, the only possible interaction is with antidepressant
medications, as StemEnhance contains phenylethylamine (PEA), a compound naturally produced by
the brain that affect dopamine and norepinephrine in the brain. PEA is known for its effect on mood
elevation and mental energy. Intereactions with antidepressant medications have not been reported,
but the possibility exists. People should consult their doctor before taking StemEnhance if they are
on antidepressant medication.

Can Stem Enhance be taken by children?
The ability of stem cells to be released by the bone marrow and the quality of the stem cells released
by the bone marrow both appears to decrease with age. Therefore, one might conclude that children
and infants have a very effective “stem cell system” and do not need stem cell support.
Nevertheless, we have received very compelling testimonials suggesting that StemEnhance could
bring significant benefits to young children. StemEnhance is made of two extracts from the
cyanophyta Aphanizomenon flos-aquae (AFA), which has been consumed by children for more than
two decades with a good history of safety.

How will I know it's working?
Most people will notice within several minutes to a few weeks that they have a greater sense of well-
being. It is common for people to notice health benefits within a few weeks of beginning
StemEnhance. Everyone is different. For some the benefits appear slowly over a period of months.
Others notice improvements almost immediately. The intent is to improve overall health.

How long should I take StemEnhance?
Considering our bodies did not deteriorate over night it would be foolish for us to expect them to
renew and rebuild overnight. The fact is - the more stem cells in our bodies, the better our overall
health and the quicker our bodies can renew themselves. In short, take this product as long as you
feel like it has an advantage to your health.

What evidence shows that StemEnhance is safe for long-term use?
AFA, the raw ingredient from which StemEnhance is derived, has been on the marketplace for more
than two decades with a very good track record of safety. A safety study in mice determined that
consumption of the equivalent of up to 2,000 AFA capsules daily led to no health problems at all. In
fact, the authors claimed that the mice receiving the highest dose of AFA were less aggressive and
looked healthier. StemEnhance is a 5:1 concentrate of AFA, and just like 5:1 concentrates of
echinacea or grape seed or ginkgo or wheat grass juice that are as safe as the whole plant they are
derived from, StemEnhance is as safe as whole AFA. StemEnhance is to whole AFA what carrot juice is
to a whole carrot. The question may also refer to the safety of increasing the number of circulating
stem cells everyday by 25-30%. Here also the safety is unquestionable. The normal range for the
number of circulating stem cells is between 1.2 and 5.0 stem cells per µL of blood. An increase of 30%
in the number of circulating stem cells would at most mean an increase of 1.5 cells per µL, which is
well within normal physiological range. Looking at this from a different angle, Krause et al. [7]
reported that one single stem cell was enough to reconstitute the entire hematopoietic (red blood
cell) and immune systems. If one single stem cell can do this, then the billions of stem cells left in the
bone marrow after taking StemEnhance can maintain a healthy and strong bone marrow.

Is StemEnhance FDA approved?
No. FDA does not approve dietary supplements in the same way that FDA approves some drugs and
medical devices. Nonetheless, FDA does regulate product quality, product safety, and product claims,
and has authority to remove products from the market that are not safe or that make claims that are
not substantiated by scientific evidence.
Is StemEnhance truly natural? Organic? Non-genetically modified? Farmed?
StemEnhance is made of two extracts from the aquatic botanicals Aphanizomenon flos-aquae (AFA).
AFA grows naturally in a pristine lake of Southern Oregon, it is therefore wildcrafted, not farmed or
manipulated in anyway, hence no genetic modification. StemEnhance is produced by an Organic
certified facility and is certified Organic.

What are the ingredients?
The ingredients are listed in the Supplement Fact box of the label, as stipulated by the Dietary
Supplement Health and Education Act. One serving is obtained with 2 capsules, totaling 1 gram of
cyanophyta extracts. StemEnhance is made of only two ingredients that are extracted from the same
plant, Aphanizomenon flos-aquae. Labeling laws require listing any nutrient found in an amount
superior to 2% of the daily recommendation. Carotenoids and proteins are found in significant amount
in StemEnhance. Therefore, carotenoids and proteins that are naturally present in StemEnhance are
listed on the label. Carotenoids are listed as vitamin A because they are measured as retinal
equivalent.

Are there any synthetic ingredients in StemEnhance? If so, what?
StemEnhance is made of 100% natural AFA extracts. At times, carrageenan, a seaweed extract, can be
used in small amount as a processing aid.

How is StemEnhance different from whole AFA?
Whole AFA has been used for more than two decades with a very good track record of safety and
health benefits. Whole AFA has been used as a natural anti-inflammatory product, to support the
immune system, and to improve mental clarity and mental energy. Over the past few years StemTech’s
scientific team has isolated and identified the various components in AFA responsible for the various
health benefits of AFA. In brief, AFA has been found to contain phenylethylamine (PEA) responsible
for providing a feeling of mental energy, phycocyanin responsible for the antioxidant and anti-
inflammatory properties, a polysaccharide responsible for supporting the immune system, and most
recently an L-selectin ligand responsible for supporting the release of stem cells from the bone
marrow.
StemEnhance is a 5:1 concentrate of AFA that concentrates the four compounds listed above. It is
specifically designed and developed to support stem cell physiology, but it also concentrates other
compounds unique to AFA, bringing unique support for the whole body.

What are other ways of increasing your stem cell blood level?
Due to the novelty of the concept of supporting the release of one’s own stem cells, very little
scientific work has been done so far to identify compounds or conditions that increase the release of
stem cells from the bone marrow. So far, StemEnhance is the only natural compound shown to
support the release of stem cells from the bone marrow.

For whom is the product advisable?
Since StemEnhance supports the natural release of stem cells from the bone marrow, which is turn
travel throughout the body to maintain the health of various organs and tissues. StemEnhance is the
optimal daily support for the maintenance of optimal health. It is for everyone interested in giving
their body an extra boost toward daily renewal of cells throughout the body. It is for anyone
interested in supporting his or her body’s natural renewal system.

Is StemEnhance safe for my pet?
Yes, it's perfectly safe for all animals and pets. Several animal studies have been done. Mix ½
capsule into moist food, once or twice per day, for small animals such as cats or small dogs.
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