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Low Chloress
Policosanol

Policosanol Helps Reduce High Cholesterol

Policosanol is an all-natural substance derived from the wax of sugar cane, or
extracted from the wax of honey bees. It is helpful in reducing cholesterol levels
in people with abnormally high cholesterol, and in so doing it improves your
heart health. High cholesterol can lead to serious health problems, including
heart disease, the number one killer in the U.S., and stroke. Policosanol is
relatively new to the United States market, but appears to be a promising new
agent in the fight against cardiovascular disease with minimal if any side effects!

While the benefits of policosanol have been proven in several well-designed
clinical studies mentioned below, the exact mechanism of action is not
completely understood. It inhibits cholesterol manufacture but appears to do so
prior to HMG-CoA reductase, where the commercially prescribed cholesterol
lowering medications such as Lipitor, Zocor and Crestor act. In addition
policosanol also exerts effects on LDL –cholesterol metabolism. Specifically, it
increases LDL receptor processing. It exerts this effect by increasing the
binding of LDL to it receptor, improving the transport of LDL into the liver cell,
and significantly enhancing the breakdown of LDL cholesterol It also appears to
promote normal cholesterol uptake by the body’s tissues.

Numerous controlled studies have shown that policosanol is an effective
treatment for elevated cholesterol. In one study, participants received 20 or 40
mg per day of policosanol or a placebo for six months. Total cholesterol and LDL
(“bad”) cholesterol decreased significantly and the HDL (“good”) cholesterol
increased in both groups that received policosanol, while none of the
cholesterol markers changed in those taking a placebo. The researchers also
found that taking 40 mg per day of policosanol was no more effective than taking
20 mg per day, which suggests that the lower amount is sufficient in most people
to reduce the levels of “bad” cholesterol.

In a six-month study, 10mg per day of policosanol reduced total cholesterol by
16% and LDL cholesterol by 24%, and increased HDL cholesterol by 29%. Several
other studies have complared policosanol with some of the conventional
medications used for lowering cholesterol. The results have shown policosanol,
in the amount of 5 to 20 mg per day, to be as or more effective than lovastatin
(Mevacor), pravastatin (Pravachol), and problems in rare instances, people
taking policosanol have not suffered any serious side effects – an important
benefit!

Policosanol may also be helpful for other conditions. A two-year study showed
that 20 mg per day of policosanol significantly improved lower leg pain during
walking in people with hardening of the arteries in the legs (intermittent
claudicaation). Policosanol may also help prevent blodd clots by thinning the
blood; in one study it was as effective a blood thinner as 100 mg per day of
aspirin. The combination of policosanol and aspirin was even more effective
than either treatment alone.


Policosanol Comparison

Several different versions of policosanol are available on the market – and of
course all claim to be the best!  Are these products equivalent, and how do you
decide and choose the best product?

Some are derived from rice bran or beeswax and others from sugar cane wax.
There are numerous stuies investigating the befeficial effects of policosanol, the
majoruity of them were conducted in Cuba using the patented Cuban policosanol
sourced from sugar cane wax. As a result, this highly researched form of
policosanol is considered the gold standard of policosanol products. Cuban
policosanol is a blend of natural concentrated fatty alcohols, the predominant
one being octacosanol, which makes up roughly 60% of the mixture. The fatty
alcohol compositions of the beeswax and rice bran derived policosanol products
fail to measure up to the Cuban material. In fact, most of these products have
completely different fatty alcohol proviles than the Cuban version, with most of
the fatty alcohols falling outside of the Cuban material specification ranges.